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<800> Hazardous Drugs—Handling in Healthcare Settings

Type of Posting: Notice of Intent to Revise

Posting Date: 15–Apr–2016; updated 29–Apr–2016*

Targeted Official Date: 26–May–2016; Errata

Expert Committee: Compounding Expert Committee

In accordance with section 7.04 (c) of the 2015–2020 Rules and Procedures of the Council of Experts, this is to provide notice that the USP Compounding Expert Committee intends to revise General Chapter <800> Hazardous Drugs—Handling in Healthcare Settings.

The Expert Committee proposes to revise the General Chapter to remove the requirement that the Containment Secondary Engineering Control (C-SEC) be externally vented through high-efficiency particulate air (HEPA) filtration. Section 5.3 FACILITIES AND ENGINEERING CONTROLS, Compounding will be revised to indicate that the C-SEC used for sterile and nonsterile compounding must be externally vented. The C-SEC does not need to be vented through HEPA filtration.

The proposed revisions will be published as Errata pursuant to section 7.02 of the Rules and Procedures. The proposed Errata will be included in the Errata table update on May 26, 2016, which will become official on June 1, 2016. The correction will be incorporated into the next USP–NF publication. The official date of General Chapter <800> will remain July 1, 2018.

Should you have any questions, please contact Jeanne Sun, Scientific Liaison to the Compounding Expert Committee (

*The notice was updated on April 29, 2016 to specify that the revision will be published as Errata on May 26, 2016.