Accelerated Revisions by Official Date

Revision Bulletins are posted by the first of each month. Each Revision Bulletin includes the reason for the change and the complete Monograph or General Chapter Revision Bulletins are transferred to the Accelerated Revision History section when the standard is published and becomes official in the next USP–NF publication. For more information on the Revision Bulletins and the Accelerated Revision process, see USP's Guideline on the Use of Accelerated Processes for Revisions to USP–NF. See here for specific posting and official dates.

To view Revision Bulletins in alphabetical order please click here.

IRAs are published in Pharmacopeial Forum (PF) as proposed IRAs. After a 90-day notice and comment period and approval by the relevant USP Expert Committee, IRAs are posted as official text in this location of the USP website, and are incorporated into the next available official publication (USP–NF or Supplement) at which time the posting may also be found in the Accelerated Revision History. Official IRAs are no longer published in PF. The PF posting dates, comment deadlines and IRA posting and official dates are outlined here.

To view Interim Revision Announcements in alphabetical order, please click here.

Official May 2026

• <665> Plastic Components and Systems Used to Manufacture Pharmaceutical Drug Products and Biopharmaceutical Drug Substances and Products Notice and Chapter (RB posted 29-Apr-2022; official 01-May-2026)

Official November 2023

• Albuterol Inhalation Solution Notice and Monograph (RB posted 30–Apr–2021; official 01–Nov–2023)

Official July 2023

• <7> Labeling (IRA posted 31–Jul–2020; official 01–Sep–2023)

Official May 2023

• Acyclovir Notice and Monograph (RB posted 29-Apr-2022; official 01-May-2023)
• Magnesium Sulfate Notice and Monograph (RB posted 25–Feb–2022; official 01–May–2023)

Official December 2022

• Magnesia Tablets Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022)
• Magnesium Carbonate Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022)
• Magnesium Hydroxide Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022)
• Magnesium Hydroxide Paste Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022)
• Magnesium Oxide Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022)
• Magnesium Trisilicate Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022)
• Milk of Magnesia Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2022) 

Official August 2022

• Calcipotriene Ointment Notice and Monograph (RB posted 29-Apr-2022; official 01-Aug-2022)
• Fondaparinux Sodium Notice and Monograph (RB posted 29-Apr-2022; official 01-Aug-2022)

Official July 2022

• Dextran 40 Notice and Monograph (RB posted 25–Mar–2022; official 01–Jul–2022)
• Dextran 70 Notice and Monograph (RB posted 25–Mar–2022; official 01–Jul–2022)

Official June 2022

• Azithromycin for Oral Suspension Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)
• Dextrose Injection Notice and Monograph (RB posted 29-Apr-2022; official 01-Jun-2022)
• Diethylene Glycol Stearates Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)
• Hydroxychloroquine Sulfate Tablets Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)
• Levothyroxine Sodium Tablets Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)
• Loratadine Capsules Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)
• Methylprednisolone Tablets Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)
• Potassium Citrate Extended-Release Tablets Notice and Monograph (RB posted 27–May–2022; official 01–Jun–2022)

Official May 2022

• Abiraterone Acetate Tablets Notice and Monograph (RB posted 04–May–2022; official 05–May–2022)
• Carbidopa and Levodopa Orally Disintegrating Tablets Notice and Monograph (RB posted 29-Apr-2022; official 01-May-2022)
• Carbidopa and Levodopa Tablets (IRA posted 25–Mar–2022; official 01–May–2022)
• Methylprednisolone Sodium Succinate for Injection Notice and Monograph (RB posted 04–May–2022; official 05–May–2022) 
• Paclitaxel (IRA posted 25–Mar–2022; official 01–May–2022)
• Tetracycline (IRA posted 25–Mar–2022; official 01–May–2022)
• Tetracycline Hydrochloride (IRA posted 25–Mar–2022; official 01–May–2022)
• Tetracycline Hydrochloride Capsules (IRA posted 25–Mar–2022; official 01–May–2022)
• Vancomycin Injection Notice and Monograph (posted 29-Apr-2022; official 01-May-2022)

Official April 2022

• Chlorzoxazone Tablets Notice and Monograph (RB posted 25–Mar–2022; official 01–Apr–2022)
• Metformin Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 25–Mar–2022; official 01–Apr–2022)
• Metolazone Tablets Notice and Monograph (RB posted 14–Apr–2022; official 15–Apr–2022)
• Nicardipine Hydrochloride Injection Notice and Monograph (RB posted 25–Mar–2022; official 01–Apr–2022)
• Oseltamivir Phosphate Capsules Notice and Monograph (RB posted 25–Mar–2022; official 01–Apr–2022)

Official March 2022

• Abacavir Oral Solution Notice and Monograph (RB posted 25–Feb–2022; official 01–Mar–2022)
• Aripiprazole Tablets Notice and Monograph (RB posted 25–Feb–2022; official 01–Mar–2022)
• Diclofenac Potassium for Oral Solution Notice and Monograph (posted 30–Mar–2022; official 31–Mar–2022)
• Divalproex Sodium Extended-Release Tablets Notice and Monograph (RB posted 16–Mar–2022; official 17–Mar–2022)
• Methotrexate (IRA posted 28–Jan–2022; official 01–Mar–2022)
• Selenemethionine (IRA posted 28–Jan–2022; official 01–Mar–2022)

Official February 2022

• Azeotropic Isopropyl Alcohol Notice and Monograph (RB posted 30–Jul–2021; official 01–Feb–2022)
• Doxepin Hydrochloride Capsules Notice and Monograph (RB posted 28–Jan–2022; official 01–Feb–2022)
• Isopropyl Alcohol Notice and Monograph (RB posted 30–Jul–2021; official 01–Feb–2022)
• Metformin Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 28–Jan–2022; official 01–Feb–2022)
• Nandrolone Decanoate Notice and Monograph Notice and Monograph (RB posted 28–Jan–2022; official 01–Feb–2022)

Official January 2022

• Desipramine Hydrochloride Tablets Notice and Monograph (RB posted 31–Dec–2021; official 01–Jan–2022)
• Ipratropium Bromide Inhalation Solution (IRA posted 19–Nov–2021; official 01–Jan–2022)
• Metformin Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 06–Jan–2022; official 07–Jan–2022)
• Orlistat (IRA posted 19–Nov–2021; official 01–Jan–2022)
• Orlistat Capsules (IRA posted 19–Nov–2021; official 01–Jan–2022)

Official December 2021

• Baclofen Injection Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2021)
• Metformin Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2021)
• Quetiapine Extended-Release Tablets Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2021)
• Starch TS Notice and Monograph (RB posted 19–Nov–2021; official 01–Dec–2021)

Official November 2021

• Acetaminophen Oral Suspension Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Alprazolam Tablets Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Amoxicillin Capsules Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Amoxicillin Tablets Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Bupropion Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021
• Chlordiazepoxide Hydrochloride and Clidinium Bromide Capsules Notice and Monograph (RB posted 04–Nov–2021; official 05–Nov–2021)
• Dexamethasone Tablets Notice and Monograph (RB posted 02–Nov–2021; official 03–Nov–2021)
• Diphenhydramine Hydrochloride Capsules Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Diphenhydramine Hydrochloride Oral Solution Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Diphenhydramine and Phenylephrine Hydrochlorides Tablets Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Divalproex Sodium Delayed-Release Capsules Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Glycine Notice and Monograph (posted 29–Oct–2021; official 01–Nov–2021)
• Phenylephrine Hydrochloride Tablets Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)
• Rotigotine Notice and Monograph (RB posted 29–Oct–2021; official 01–Nov–2021)

Official October 2021

• Quinidine Gluconate Extended-Release Tablets Notice and Monograph (RB posted 07–Oct–2021; official 08–Oct–2021)

Official September 2021

• Mercaptopurine (IRA posted 30–Jul–2021; official 01–Sep–2021)
• Metformin Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 16–Sep–2021; official 17–Sep–2021)
• Quetiapine Extended-Release Tablets Notice and Monograph (RB posted 27–Aug–2021; official 01–Sep–2021)
• Tranexamic Acid Tablets Notice and Monograph (RB posted 27–Aug–2021; official 01–Sep–2021)

Official August 2021

• Bupropion Hydrochloride Notice and Monograph (RB posted 30–Apr–2021; official 01–Aug–2021) | En español
• Nifedipine Extended-Release Tablets Notice and Monograph (RB posted 30–Jul–2021; official 01–Aug–2021)
• Olmesartan Medoxomil Tablets Notice and Monograph (RB posted 30–Jul–2021; official 01–Aug–2021)
• Potassium Chloride Extended-Release Tablets Notice and Monograph (RB posted 30–Jul–2021; official 01–Aug–2021)
• Sucrose Notice and Monograph (RB posted 30–Jul–2021; official 01–Aug–2021)

Official July 2021

• Baclofen Injection Notice and Monograph (RB posted 25–Jun–2021; official 01–Jul–2021)
• Benztropine Mesylate Notice and Monograph (RB posted 25–Jun–2021; official 01–Jul–2021) 
• Budesonide Notice and Monograph (RB posted 25–Jun–2021; official 01–Jul–2021)
• Oxcarbazepine Oral Suspension Notice and Monograph (RB posted 28–Jul–2021; official 29–Jul–2021)
• Potassium Citrate Extended-Release Tablets Notice and Monograph (RB posted 25–Jun–2021; official 01–Jul–2021)

Official June 2021

• (+)-1-(9-Fluoroenyl) ethyl Chloroformate Solution Reagent and Notice (RB posted 28–May–2021; official 01–Jun–2021) | En español
• Buspirone Hydrochloride Tablets Monograph and Notice (RB posted 28–May–2021; official 01–Jun–2021) | En español
• Chlorpromazine Hydrochloride Oral Concentrate Notice and Monograph (RB posted 14–Jun–2021; official 15–Jun–2021) 
• Lovastatin Tablets Monograph and Notice (RB posted 28–May–2021; official 01–Jun–2021) | En español
• Mesalamine Delayed-Release Tablets Monograph and Notice (RB posted 28–May–2021; official 01–Jun–2021) | En español
• Nitrofurantoin Capsules Monograph and Notice (RB posted 28–May–2021; official 01–Jun–2021) | En español

Official May 2021

• Abiraterone Acetate Tablets Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Benazepril Hydrochloride and Hydrochlorothiazide Tablets Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Benztropine Mesylate (RB posted 29–Feb–2021; official 01–May–2021) | En español
• Chlorzoxazone Tablets Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Clonidine Hydrochloride Extended-Release Tablets Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Codeine Phosphate Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Doxepin Hydrochloride Capsules (RB posted 18–Dec–2020; official 01–May–2021) | En español
• Doxepin Hydrochloride Capsules Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021)| En español
• Fenofibrate Capsules Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Gemfibrozil Tablets (IRA posted 26–Mar–2021; official May 1, 2021) | En español
• Ioversol (IRA posted 26–Mar–2021; official May 1, 2021) | En español
• Ioversol Injection (IRA posted 26–Mar–2021; official May 1, 2021) | En español
• Lactobacillus rhamnosus (RB posted 18–Dec–2020; official 01–May–2021) | En español
• Lauroyl Polyoxyglycerides Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Paroxetine Hydrochloride (IRA posted 26–Mar–2021; official May 1, 2021) | En español
• Pyrazinamide Notice and Monograph (posted 30–Apr–2021; official 01–May–2021) | En español
• Rufinamide Tablets Notice and Monograph (RB posted 30–Apr–2021; official 01–May–2021) | En español
• Sulfamethoxazole (IRA posted 26–Mar–2021; official May 1, 2021) | En español

Official April 2021

• Amlodipine and Olmesartan Medoxomil Tablets (posted 26–Mar–2021; official 01–Apr–2021)
• Bupropion Hydrochloride Extended-Release Tablets (posted 26–Mar–2021; official 01–Apr–2021)
• Diclofenac Sodium Topical Solution (posted 26–Mar–2021; official 01–Apr–2021)
• Divalproex Sodium Delayed-Release Capsules (posted 26–Mar–2021; official 01–Apr–2021)
• Ethacrynic Acid Tablets (posted 26–Mar–2021; official 01–Apr–2021)
• Nifedipine Extended-Release Tablets (posted 26–Mar–2021; official 01–Apr–2021)
• Oxybutynin Chloride Tablets (posted 26–Mar–2021; official 01–Apr–2021) 

Official March 2021

• <661.1> Plastic Materials of Construction (RB posted 26–Feb–2021; official 01–Mar–2021)
• Albendazole Tablets (RB posted 02–Mar–2021; official 03–Mar–2021)
• Diltiazem Hydrochloride Extended-Release Capsules (RB posted 26–Feb–2021; official 01–Mar–2021)
• Extended Phenytoin Sodium Capsules (RB posted 26–Feb–2021; official 01–Mar–2021)
• Metformin Hydrochloride Extended-Release Tablets (RB posted 26–Feb–2021; official 01–Mar–2021)
• Temozolomide (IRA posted 31–Jul–2020; official 01–Mar–2021)
• Temozolomide Capsules (IRA posted 31–Jul–2020; official 01–Mar–2021)
• Temozolomide for Injection (IRA posted 31–Jul–2020; official 01–Mar–2021)
• Venlafaxine Hydrochloride Extended-Release Capsules (RB posted 26–Feb–2021; official 01–Mar–2021)

Official February 2021

• Amiodarone Hydrochloride Tablets (RB posted 29–Jan–2021; official 01–Feb–2021)
• Ropivacaine Hydrochloride (RB posted 23–Feb–2021; official 24–Feb–2021)

Official January 2021

• Bupropion Hydrochloride Extended-Release Tablets (RB posted 18–Dec–2020; official 01–Jan–2021)
• Fexofenadine Hydrochloride Tablets (RB posted 18–Dec–2020; official 01–Jan–2021)
• Filgrastim (IRA posted 20–Nov–2020; official 01–Jan–2021)
• Metformin Hydrochloride Extended-Release Tablets (RB posted 18–Dec–2020; official 01–Jan–2021)
• Methylphenidate Hydrochloride Extended-Release Tablets (RB posted 18–Dec–2020; official 01–Jan–2021)
• Minocycline Hydrochloride Extended-Release Tablets (RB posted 18–Dec–2020; official 01–Jan–2021)
• Nicotine Transdermal System (RB posted 18–Dec–2020; official 01–Jan–2021)
• Potassium Chloride Extended-Release Capsules (RB posted 18–Dec–2020; official 01–Jan–2021)

Official December 2020

• <825> Radiopharmaceuticals— Preparation, Compounding, Dispensing, and Repackaging (RB posted 29–May–2020; official 01–Dec–2020)
• Calcium Acetate Capsules (RB posted 20–Nov–2020; official 01–Dec–2020)
• Polyethylene Glycol 3350 (RB posted 20–Nov–2020, updated 25–Nov–2020; official 01–Dec–2020)

Official November 2020

• Fondaparinux Sodium Injection (RB posted 30–Oct–2020; official 01–Nov–2020)
• Loperamide Hydrochloride (RB posted 29–May–2020; official 01–Nov–2020)
• Mesalamine Delayed-Release Tablets (RB posted 24–Apr–2020; updated 01–May–2020; official 01–Nov–2020)
• Mesalamine Delayed-Release Tablets (RB posted 31–Jul–2020; official 01–Nov–2020)
• Metoprolol Succinate Extended-Release Tablets (RB posted 30–Oct–2020; official 01–Nov–2020)
• Nitrofurantoin Capsules (RB posted 30–Oct–2020; official 01–Nov–2020)
• Parachlorophenol (RB posted 30–Oct–2020; official 01–Nov–2020)
• Potassium Citrate Extended-Release Tablets (RB posted 30–Oct–2020; official 01–Nov–2020)

Official October 2020

• Doxycyline Hyclate Delayed-Release Tablets (RB posted 25–Sep–2020; official 01–Oct–2020)
• Ethacrynic Acid Tablets (RB posted 25–Sep–2020; official 01–Oct–2020)
• Methylphenidate Hydrochloride Extended-Release Tablets (RB posted 25–Sep–2020; official 01–Oct–2020)

Official September 2020

• Alcohol (RB posted 17–Aug–2020; official 01–Sep–2020)
• Clonidine Transdermal System (RB posted 28–Aug–2020; official 01–Sep–2020)
• Chlorpromazine Hydrochloride Tablets (RB posted 15–Sep–2020; official 16–Sep–2020)
• Dehydrated Alcohol (RB posted 17–Aug–2020; official 01–Sep–2020)
• Dextrose Excipient (RB posted 28–Aug–2020; official 01–Sep–2020)
• Dopamine Hydrochloride Injection (RB posted 28–Aug–2020; official 01–Sep–2020)
• Metaxolone Tablets (RB posted 28–Aug–2020; official 01–Sep–2020)
• Metyrosine Capsules (RB posted 21–Sep–2020; official 22–Sep–2020)
• Naloxone Hydrochloride Injection (RB posted 28–Aug–2020; official 01–Sep–2020)
• Travoprost Ophthalmic Solution (IRA posted 31–Jul–2020; official 01–Sep–2020)

Official August 2020

• Buprenorphine and Naloxone Sublingual Tablets (RB posted 31–Jul–2020; official 01–Aug–2020)
• Niacin Extended-Release Tablets (RB posted 31–Jul–2020; official 01–Aug–2020)
• Propafenone Hydrochloride Extended-Release Capsules (RB posted 06–Aug–2020; official 07–Aug–2020)
• Propranolol Hydrochloride Extended-Release Capsules (RB posted 31–Jul–2020; official 01–Aug–2020)
• Quinine Sulfate Capsules (RB posted 31–Jul–2020; official 01–Aug–2020)

Official July 2020

• <800> Hazardous Drugs–Handling in Healthcare Settings (RB posted 26–Jun–2020; official 01–Jul–2020)
• Clomipramine Hydrochloride Capsules (RB posted 07–Jul–2020; official 08–Jul–2020)
• Esomeprazole Magnesium Delayed-Release Capsules (RB posted 26–Jun–2020; official 01–Jul–2020)
• Fluphenazine Hydrochloride Tablets (RB posted 20–Jul–2020; official 21–Jul–2020)
• Prazosin Hydrochloride Capsules (RB posted 26–Jun–2020; official 01–Jul–2020)
• Propafenone Hydrochloride Extended-Release Capsules (RB posted 06–Aug–2020; official 07–Aug–2020)
• Prednisone Tablets (RB posted 07–Jul–2020; official 08–Jul–2020)

Official June 2020

• Amiodarone Hydrochloride Tablets (RB posted 29–May–2020; official 01–Jun–2020)
• Mesalamine Extended-Release Capsules (RB posted 29–May–2020; official 01–Jun–2020)
• Montelukast Sodium Chewable Tablets (RB posted 29–May–2020; official 01–Jun–2020)
• N-Acetylglucosamine (RB posted 29–May–2020; official 01–Jun–2020)
• Nifedipine Extended-Release Tablets (RB posted 22–Nov–2019; official 01–May–2020) | En español
• Olanzapine Tablets (RB posted 24–Apr–2020; official 01–May–2020)

Official May 2020

• <795> Pharmaceutical Compounding— Nonsterile Preparations (RB posted 24–Apr–2020; official 01–May–2020)
• <797> Pharmaceutical Compounding— Sterile Preparations (RB posted 24–Apr–2020; official 01–May–2020)
• Atomoxetine Capsules (RB posted 31–Jan–2020; official 01–May–2020)
• Bendamustine Hydrochloride (RB posted 22–Feb–2019; official 01–Mar–2019) | En español 
• Carbamazepine Extended-Release Tablets (RB posted 26–Dec–2019; official 01–May–2020)
• Cyclobenzaprine Hydrochloride (RB posted 26–Dec–2019; official 01–May–2020)
• Diphenydramine Hydrochloride and Ibuprofen Capsules (RB posted 24–Apr–2020; official 01–May–2020)
• Donepazil Hydrochloride Tablets (RB posted 24–Apr–2020; official 01–May–2020)
• Doxycycline Hyclate Tablets (RB posted 28–Feb–2020; official 01–May–2020)
• Extended Insulin Zinc Suspension (RB posted 29–Mar–2019; official 01–May–2019) | En español
• Goserelin Acetate (IRA posted 27–Mar–2020; official 01–May–2020)
• Mesalamine Delayed-Release Tablets (RB posted 22–Nov–2019; 01–May–2020) | En español
• Montelukast Sodium Tablets (RB posted 22–Nov–2019; official 01–May–2020) | En español
• Nifedipine Extended-Release Tablets (posted 22–Nov–2019; official 01–May–2020) | En español
• Zolmitriptan (IRA posted 27–Mar–2020; official 01–May–2020)

Official April 2020

• Drospirenone and Ethinyl Estradiol Tablets (RB posted 29–Mar–2019; official 01–Apr–2019) | En español
• Metformin Hydrochloride Extended-Release Tablets (RB posted 27–Apr–2020; official 28–Apr–2020)

Official March 2020

• Potassium Chloride Extended-Release Tablets (RB posted 23–Mar–2020; official 24–Mar–2020)
• Amlodipine and Olmesartan Medoxomil Tablets (RB posted 28–Feb–2020; official 01–Mar–2020)

Official February 2020

• Diltiazem Hydrochloride Extended-Release Capsules (RB posted 31–Jan–2020; official 01–Feb–2020)
• Fluconazole Tablets (RB posted 31–Jan–2020; official 01–Feb–2020)
• Olmesartan Medoxomil Tablets (RB posted 31–Jan–2020; official 01–Feb–2020)

Official January 2020

• Calcium Acetate Capsules (RB posted 26–Dec–2019; official 01–Jan–2020)
• Doxycycline Calcium Oral Suspension (RB posted 26–Dec–2019; official 01–Jan–2020)
• Formoterol Fumarate (IRA posted 22–Nov–2019; official 01–Jan–2020)
• Levetiracetam Extended-Release Tablets (RB posted 26–Dec–2019; official 01–Jan–2020)

Revisions Official in 2019

Revisions Official in 2018