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PDF CSV March 29, 2022 through March 29, 2024 See all Errata for USP–NF How to use
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Monograph Title Section Source Publication Page Number Errata Official Date Target Errata Print Publication Target Online Fix Publication Sort descending Description
HOMATROPINE HYDROBROMIDE CHEMICAL INFORMATION USPNF Online Online 1-Jul-2022 NA NA Change
356.25
to:
356.26
AND
Change
1αH,5αH-Tropan-3α-ol mandelate (ester) hydrobromide
to:
(1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-phenylacetate hydrobromide
LYSINE HYDROCHLORIDE IMPURITIES/Related Compounds USPNF Online Online 1-Jun-2023 NA NA In Chromatographic system/Spray reagent: Change
0.2 g of ninhydrin in a mixture of butyl alcohol and 2 N acetic acid (95:5)
to:
2 mg/mL of ninhydrin in a mixture of butyl alcohol and 2 N acetic acid (95:5)
LINEZOLID TABLETS IMPURITIES/Organic Impurities USPNF Online Online 1-Jun-2023 NA NA In Sensitivity solution: Change
0.5 ug/mL of USP Linezolid RS from Standard solution in Diluent
to:
0.5 μg/mL of USP Linezolid RS from Standard solution in Diluent
AMOXICILLIN BOLUSES IDENTIFICATION USPNF Online Online 1-Dec-2023 NA NA Change
Application volume, Developing solvent system, Procedure—Proceed as directed for the Identification test under Amoxicillin Tablets.
to:
Application volume—5 µL.
Developing solvent system… Read More
BROMOCRIPTINE MESYLATE CAPSULES PERFORMANCE TESTS/Dissolution <711> USPNF Online Online 1-May-2022 NA NA In Analysis: Change
bromocriptine mesylate (C32H40BrN5O5 · CH4SO3)
to:
bromocriptine (C32H40BrN5O5)
AND
In… Read More
CALCIUM L-5-METHYLTETRAHYDROFOLATE ASSAY/Procedure USPNF Online Online 1-Nov-2022 NA NA In System suitability solution: Change
USP Calcium DL-5-Methyltetrahydrofolate RS
to:
USP Calcium D,L-5-Methyltetrahydrofolate RS
AND
In Standard solution: Change
USP Calcium DL-5-Methyltetrahydrofolate RS
to:
USP Calcium D,L-5-… Read More
THYROID ASSAY/Procedure USPNF Online Online 1-Apr-2023 NA NA In Chromatographic system: Change
Column: 4.6-cm × 25-cm; packing L1
to:
Column: 4.6-mm × 25-cm; packing L1
BLACK CUMIN SEED THYMOQUINONE OIL DEFINITION USPNF Online Online 1-Sep-2023 NA NA Change
carvacol
to:
carvacrol
ENSULIZOLE IDENTIFICATION USPNF Online Online 1-Apr-2024 NA NA In B.: Change
The retention time of the major peak of the Sample solution exhibits maxima and minima at the same wavelengths as those of the Standard solution, as obtained in the Assay.
to:
The retention time of the major… Read More
DOFETILIDE CHEMICAL INFORMATION USPNF Online Online 1-Nov-2022 NA NA Change
β-[(p-Methanesulfonamidophenethyl)methylamino]methane sulfono-p-phenetidide
to:
N-{4-[2-(Methyl{2-[4-(methylsulfonamido)phenoxy]ethyl}amino)ethyl]phenyl}methanesulfonamide
ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE TABLETS ADDITIONAL REQUIREMENTS/USP Reference Standards 〈11〉 USPNF Online Online 1-Apr-2023 NA NA Change
USP 2-Methylbenzhydrol RS
to:
USP Methylbenzhydrol RS
ZIPRASIDONE CAPSULES IMPURITIES USPNF Online Online 1-Sep-2023 NA NA In Organic Impurities/Solution B: Change
potassium hydroxide
to:
potassium hydroxide solution
AND
In Organic Impurities/Analysis: Change
449.40
to:
449.39
LATANOPROST ASSAY/Procedure USPNF Online Online 1-Dec-2022 NA NA Change
Standard solution: Transfer 2.0 mg/mL of USP Latanoprost RS into a suitable volumetric flask, dissolve in dehydrated alcohol equivalent to 20% of the final volume, and dilute with chromatographic hexane to volume.
Sample solution:… Read More
CHLOROPROCAINE HYDROCHLORIDE INJECTION ASSAY/Procedure USPNF Online Online 1-Feb-2023 NA NA In Sample solution: Change
Transfer about 100 mg of chloroprocaine hydrochloride to a 100-mL volumetric flask, dissolve in 40 mL of methanol, and dilute with water to volume.
to:
Transfer a volume of Injection, equivalent to about 100 mg of… Read More
TIOCONAZOLE ADDITIONAL REQUIREMENTS/USP Reference Standards 〈11〉 USPNF Online Online 1-Jul-2023 NA NA In USP Tioconazole Related Compound A RS: Change
389.73
to:
389.72
AND
In USP Tioconazole Related Compound B RS: Change
458.62
to:
458.60
AND
In USP Tioconazole Related Compound C RS: Change
C16H13BrCl2… Read More
CEFDINIR IMPURITIES USPNF Online Online 1-Dec-2023 NA NA In Organic Impurities/Table 2/footnote a: Change
1N-[(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetyl]glycine.
to:
N-[(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetyl]glycine.
DOXYCYCLINE HYCLATE CHEMICAL INFORMATION USPNF Online Online 1-Jun-2022 NA NA Change
1025.87
to:
1025.88
DOXYCYCLINE HYCLATE TABLETS ADDITIONAL REQUIREMENTS/USP Reference Standards <11> USPNF Online Online 1-Jul-2022 NA NA In USP Doxycycline Related Compound A RS: Change
444.43
to:
444.44
AND
Change
(4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide… Read More
ADIPIC ACID IMPURITIES/Related Substances USPNF Online Online 1-Dec-2022 NA NA In Table 2: Change
Pimelic acid 1.21 0.91
Valeric acid 1.21 0.91
to:
Pimelic acid 1.21 0.91
Valeric acid 1.46 0.88
DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE CAPSULES IDENTIFICATION USPNF Online Online 1-May-2023 NA NA Change
A. The UV-Vis spectrum of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
to:
A. The UV spectrum of the major peak of the Sample solution… Read More
UREA SPECIFIC TESTS USPNF Online Online 1-Nov-2023 NA NA In Alcohol-Insoluble Matter/Sample solution: Change
100 mg/mL of Urea dissolved in warm alcohol
to:
Dissolve 5.0 g of Urea in 50 mL of warm alcohol.
AND
In Alcohol-Insoluble Matter/Analysis: Change
If any insoluble… Read More
POWDERED VALERIAN EXTRACT DEFINITION USPNF Online Online 1-Apr-2022 NA NA Change
calculated as the sum of hydroxyvalerenic acid, acetoxyvalerenic acid, and valerenic acid, on the dried basis.
to:
calculated as the sum of hydroxyvalerenic acid, acetoxyvalerenic acid, and valerenic acid, on the anhydrous basis.
<467> RESIDUAL SOLVENTS USP REFERENCE STANDARDS <11> USPNF Online Online 1-Sep-2022 NA NA Change
USP Residual Solvent Class 2—Mixture C RS
to:
USP Residual Solvents Class 2—Mixture C RS
SOTALOL HYDROCHLORIDE IMPURITIES/Organic Impurities USPNF Online Online 1-Mar-2023 NA NA In Analysis: Change
Calculate the percentage of any unspecified impurities in the portion of Sotalol Hydrochloride taken:
Result = (rU/rS) × (CS/CU) × 100
r… Read More
CLOMIPHENE CITRATE TABLETS IMPURITIES/Organic Impurities USPNF Online Online 1-Aug-2023 NA NA In Table 2: Change
Clomiphene related compound A 0.87 – 2.0
to:
Clomiphene related compound A 0.87 1.0 2.0
LINEZOLID TABLETS PERFORMANCE TESTS USPNF Online Online 1-Feb-2024 NA NA In Dissolution 〈711〉/Test 1/Analysis: Change
Result = (rU/rS) × CS × V × (1/L) × 100
rU = peak response of linezolid from the Sample… Read More
MELENGESTROL ACETATE CHEMICAL INFORMATION USPNF Online Online 1-Jul-2022 NA NA Change
396.52
to:
396.53
LYSINE ACETATE IMPURITIES/Related Compounds USPNF Online Online 1-Jun-2023 NA NA In Chromatographic system/Spray reagent: Change
0.2 g of ninhydrin in a mixture of butyl alcohol and 2 N acetic acid (95:5)
to:
2 mg/mL of ninhydrin in a mixture of butyl alcohol and 2 N acetic acid (95:5)
MILBEMYCIN OXIME CHEMICAL INFORMATION USPNF Online Online 1-Jun-2023 NA NA Change
541.68
Milbemycin B, 5-O-demethyl-28-deoxy-25-methyl-6,28-epoxy-23-hydroxyimino-, [6R,23S,25S(E)]-; (2αE,4E,5′S,6R,6′S,8E,11R,13R,15S,17αR,… Read More
AMOXICILLIN INTRAMAMMARY INFUSION IDENTIFICATION USPNF Online Online 1-Dec-2023 NA NA Change
The solution obtained responds to the Identification test under Amoxicillin Capsules.
to:
Prepare a Standard solution of USP Amoxicillin RS in 0.1 N hydrochloric acid containing 4 mg per mL. Use within 10 minutes after preparation.… Read More
ACYCLOVIR ASSAY/Procedure USPNF Online Online 1-May-2023 NA NA In the Sample solution: Change
0.1 N sodium hydroxide
to:
0.01 N sodium hydroxide
CALCIUM L-5-METHYLTETRAHYDROFOLATE IMPURITIES/Related Compounds USPNF Online Online 1-Nov-2022 NA NA In Analysis: Change
CS = concentration of USP Calcium DL-5-Methyltetrahydrofolate RS in the Standard solution (mg/mL)
to:
CS = concentration of USP Calcium D,L-5-Methyltetrahydrofolate RS in the Read More
THYROID TABLETS ASSAY/Procedure USPNF Online Online 1-Apr-2023 NA NA In Chromatographic system: Change
Column: 4.6-cm × 25-cm; packing L1
to:
Column: 4.6-mm × 25-cm; packing L1
BLACK CUMIN SEED THYMOQUINONE OIL SPECIFIC TESTS USPNF Online Online 1-Sep-2023 NA NA In Fats and Fixed Oils 〈401〉, Procedures, Fatty Acid Composition/Table 2: Change
Linoleic
to:
Linoleic acid
IPRATROPIUM BROMIDE INHALATION SOLUTION IMPURITIES USPNF Online Online 1-Apr-2024 NA NA In Organic Impurities: Change
Column: 4.6-mm × 25-µm; 5-µm packing L1
to:
Column: 4.6-mm × 25-cm; 5-µm packing L1
DOXYCYCLINE HYCLATE IMPURITIES/Organic Impurities USPNF Online Online 1-Jun-2022 NA NA In Table 2, footnote b: Change
(4S,4aR,5S,5aR,6R,12aS)-2-Acetyl-4-(dimethylamino)-4a,5a,6,12a-tetrahydro-3,5,10,12,12a-pentahydroxy-6-methyl-tetracene-1,11-dioxo-2-naphthacenecarboxamide.
to:
(4S,4aR,5S,5a… Read More
PRIMIDONE TABLETS ASSAY/Procedure USPNF Online Online 1-Dec-2022 NA NA In Sample solution: Change
0.05 mg/mL of primidone from the Standard stock solution in Diluent
to:
0.05 mg/mL of primidone from the Sample stock solution in Diluent
ROSEMARY COMPOSITION/Content of Phenolic Diterpenes USPNF Online Online 1-May-2023 NA NA In Sample solution: Change
Before injection, pass through a membrane filter of 0.45-µL or finer pore size,
to:
Before injection, pass through a membrane filter of 0.45-µm or finer pore size,
ZIPRASIDONE HYDROCHLORIDE IMPURITIES USPNF Online Online 1-Sep-2023 NA NA In Organic Impurities/Solution B: Change
Acetonitrile, methanol, and Buffer (55:5:40). Adjust with potassium hydroxide TS to a pH of 6.0.
to:
Acetonitrile, methanol, and Buffer (55:5:40). Adjust with potassium hydroxide solution… Read More
<659> PACKAGING AND STORAGE REQUIREMENTS GENERAL DEFINITIONS/Packaging Definitions Second Supplement to USP43–NF38 Online 1-Dec-2025 NA NA In Light-resistant container: Change
〈661.2〉, Functionality, Spectral Transmission Requirements for Light-Resistant Components and Systems.
to:
〈661.2〉, Functionality Test Method, Spectral Transmission Requirements for Light-… Read More
METHSUXIMIDE IMPURITIES/Organic Impurities USPNF Online Online 1-Sep-2022 NA NA In System suitability/Column efficiency: Change
NTL 5800 theoretical plates
to:
NLT 5800 theoretical plates
POTASSIUM GLUCONATE ORAL SOLUTION SPECIFIC TESTS USPNF Online Online 1-Feb-2023 NA NA Change
Alcohol Determination 〈611〉, Method II—Distillation Method:
to:
Alcohol Determination 〈611〉, Method I—Distillation Method:
METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER ADDITIONAL REQUIREMENTS/USP Reference Standards 〈11〉 USPNF Online Online 1-Jul-2023 NA NA Change
USP Methacrylic Acid and Ethyl Acrylate Copolymer (1:1) RS (USP Methacrylic Acid Copolymer, Type C RS)
to:
USP Methacrylic Acid and Ethyl Acrylate Copolymer (1:1) RS (USP Methacrylic Acid Copolymer Type C RS)
CEFDINIR ADDITIONAL REQUIREMENTS USPNF Online Online 1-Dec-2023 NA NA In USP Reference Standards 〈11〉/USP Cefdinir Related Compound A RS: Change
413.43
to:
413.42
ASCORBIC ACID INJECTION ASSAY/Procedure USPNF Online Online 1-Jul-2022 NA NA In Chromatographic system/Column: Change
150-cm × 6-mm; packing L39
to:
15-cm × 6-mm; packing L39
POTASSIUM CITRATE EXTENDED-RELEASE TABLETS PERFORMANCE TESTS/Dissolution <711> USPNF Online Online 1-Dec-2022 NA NA In Test 6: Change
Times: 0.5, 1, and 4 h—for strengths 540 and 1080 mg as potassium citrate monohydrate; 0.5, 1, and 6 h—for strength 1620 mg as potassium citrate monohydrate.
to:
Times: 0.5, 1, and 4 h—for strength 540 mg as potassium… Read More
FLUTICASONE PROPIONATE NASAL SPRAY OTHER COMPONENTS/Content of Phenylethyl Alcohol USPNF Online Online 1-May-2023 NA NA In Sample solution: Change
Transfer 1.0 g of the Nasal Spray to a 50-mL volumetric flask. Add about 40 mL of Diluent, and sonicate for 10 min until the supernatant is clear. Use the clear supernatant for analysis.
to:
Transfer 1.0 g of the… Read More
PANTOPRAZOLE SODIUM DELAYED-RELEASE TABLETS ASSAY USPNF Online Online 1-Nov-2023 NA NA In Procedure/System suitability/Tailing factor: Change
NMT 2.0, System suitability solution
to:
NMT 2.0 for pantoprazole, System suitability solution
POWDERED VALERIAN EXTRACT COMPOSITION/Content of Valerenic Acids USPNF Online Online 1-Apr-2022 NA NA In Acceptance criteria: Change
calculated as the sum of hydroxyvalerenic acid, acetoxyvalerenic acid, and valerenic acid on the dried basis
to:
calculated as the sum of hydroxyvalerenic acid, acetoxyvalerenic acid, and valerenic acid on the anhydrous… Read More
METAPROTERENOL SULFATE TABLETS Identification/A. USPNF Online Online 1-Mar-2023 NA NA Change
Proceed as directed in Identification test A under Metaproterenol Sulfate Inhalation Solution, beginning with “Allow the spots to dry”:
to:
Allow the spots to dry, and develop the chromatogram in a solvent system consisting… Read More